Studies on Chemotherapeutical Drugs. III. : Synthesis of Nitrofuran Derivatives. (2). : Preparation of (5-Nitro-2-furyl) vinyl Derivatives and their Antibacterial Activities.
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چکیده
منابع مشابه
Furan derivatives. ЬХХП. Synthesis and some properties of l-(5-nitro-2-furyl)- -2- (5-aryl-2-furyl)ethylenes
Wittig reaction has recently been applied also in the preparation of 5-nitrofuran derivatives of ethylene [1—5]. The quoted syntheses were accomplished starting either from 5-nitrofurfuryl halides which were converted into 5-nitrofurfurylidenephosphoranes and subsequent condensation of the latter with carbonyl compounds [1—4], or the intermediate phosphoranes were prepared from other furfuryl h...
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A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds <str...
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of the 27 nitrofuran derivatives tested had mutagenic effects on E. coli, but none of them had mutagenic effects on S. typhimurium. Twenty-five compounds had DNA-modifying effects on E. coli, and 24 compounds had effects on the DNA of S. typhimurium. Fifteen of the 27 compounds are known to be carcinogenic. Fourteen of these 15 carcinogenic derivatives had mutagenic effects on E. coli and DNA-m...
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Twelve 1-phenyl-, 1-thiocarbamoyl- and 1-N-substituted thiocarbamoyl-3-(2-furyl)-5-phenyl/(2-furyl)-2-pyrazoline derivatives were synthesized. The chemical structures of the compounds were proved by IR, (1)H NMR, Mass spectrometric data and microanalyses. The antidepressant activities of the compounds were investigated by Porsolt's behavioural despair (forced swimming) test on albino mice. 1-N-...
متن کاملStatistical analysis on toxicity of a nitrofuran derivative, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide.
A food additive, furylfuramide or AF-2, which had been used in Japan since 1965 and structurally is composed of 5-nitro-2-furyl radical and acrylamide, was re-examined mainly on chronic toxicity by statistically reviewing published data. The conclusions are as follows: 1) The maximum safety dosage which shows no demonstrable change in rats must be corrected at least to 1/170 of the value which ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1967
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.87.2_184